Randomised crossover comparison of skin irritation with two transdermal oestradiol patches
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منابع مشابه
Formulation, In-vitro Evaluations and Skin Irritation Study of Losartan Potassium Transdermal Patches
Losartan potassium is a well known orally active non-peptide angiotensin II receptor antagonist. Losartan potassium and its principle active metabolites block the vasoconstrictor and aldosterone secreting effect of angiotensin II by selectively blocking the binding of angiotensin II to AT1 receptors. The drug is reported to promote the decrease in ventricular hypertrophy, salt ...
متن کاملSuppression of ovulation by transdermal oestradiol patches.
implied that the indications for surgery might be more important than surgery itself. There are several potential biases. Early symptoms in women with osteoarthritis may have been misinterpreted and resulted in hysterectomy. This is unlikely given the long median delay (six years) between operation and diagnosis and that those with spinal osteoarthritis did not have the greatest rate of hystere...
متن کاملformulation, in-vitro evaluations and skin irritation study of losartan potassium transdermal patches
losartan potassium is a well known orally active non-peptide angiotensin ii receptor antagonist. losartan potassium and its principle active metabolites block the vasoconstrictor and aldosterone secreting effect of angiotensin ii by selectively blocking the binding of angiotensin ii to at1 receptors. the drug is reported to promote the decrease in ventricular hypertrophy, salt and water excreti...
متن کاملComparison of human skin irritation patch test data with in vitro skin irritation assays and animal data.
BACKGROUND Efforts to replace the rabbit skin irritation test have been underway for many years, encouraged by the EU Cosmetics Directive and REACH. Recently various in vitro tests have been developed, evaluated and validated. OBJECTIVE A key difficulty in confirming the validity of in vitro methods is that animal data are scarce and of limited utility for prediction of human effects, which a...
متن کاملDetermination of two capsaicinoids in analgesic transdermal patches using RP-HPLC and UV spectroscopy
Background and objectives: At the present time, a considerable frontier in the administration of therapeutic medications is transdermal drug delivery. Methods: In this study, a rapid, precise, sensitive and selective reversed-phasehigh performance liquid chromatography (RP-HPLC) method has been evaluated, developed and validated to separate and quantitate capsa...
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ژورنال
عنوان ژورنال: BMJ
سال: 1997
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.315.7103.288